Department of Morphological Brain Science,
Graduate School of Medicine, Kyoto University

准教授 藤山 文乃
Fumino FUJIYAMA, M.D., Ph.D., Associate Professor

updated on Jan 13, 2012

Kameda H, Hioki H, Tanaka YH, Tanaka T, Jaerin Sohn, Sonomura T, Furuta T, Fujiyama F, Kaneko T.   Parvalbumin-Producing Cortical Interneurons Receive Inhibitory Inputs on Proximal Portions and Cortical Excitatory Inputs on Distal Dendrites. Eur J Neurosci, in press
Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K, Kaneko T.   Morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors. Cerebral Cortex, in press
Tanaka YR, Tanaka YH, Konno M, Fujiyama F, Sonomura T, Okamoto-Furuta K, Kameda H, Hioki H, Furuta T, Nakamura KC, and Kaneko T.   Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex. J Neurosci, in press
Tanaka YH, Tanaka YR, Fujiyama F, Furuta T, Yanagawa Y, Kaneko T.   Local connections of layer 5 GABAergic interneurons to corticospinal neurons. Frontier in Neural Circuits, 2011
Fujiyama F, Sohn J, Nakano T, Furuta T, Nakamura KC, Matsuda W, Kaneko T.   Exclusive and common targets of neostriatofugal projections of rat striosome neurons: A single neuron-tracing study using a viral vector. Eur J Neurosci 33:668-77, 2011.  (evaluated by Kent Berridge, a Member of F1000; top 2% of published article in biology and medicine)
Kuramoto E, Fujiyama F, Nakamura KC, Tanaka Y, Hioki H, Kaneko T.   Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei. Eur J Neurosci 33:95-109, 2011
藤山文乃. (2010) 基底核ニューロンの分子マーカー Clinical Neuroscience 中外医学社 28(12):1352-1354 Review
Hioki H, Nakamura H, Ma Y-F, Konno M, Hayakawa T, Nakamura KC, Fujiyama F, Kaneko T. (2010) Vesicular Glutamate Transporter 3-Expressing Nonserotonergic Projection Neurons Constitute a Subregion in the Rat Midbrain Raphe Nuclei. J Comp Neurol 518(5):668-686 (March 1)
Published online on October 13, 2009. |  PDF |  PMID: 20034056  |  doi: 10.1002/cne.22237
藤山文乃. (2009) 大脳基底核の構造(細胞構築と神経回路) Brain and Nerve 医学書院 61(4):341-349 Review
Nakamura KC, Fujiyama F, Furuta T, Hioki H, Kaneko T. (2009) Afferent islands are larger than µ-opioid receptor patch in striatum of rat pups. NeuroReport 20(6):584-8 (April 22)
*See the cover illustration of this issue .
Published online on Mar 12, 2009. |  PDF |  PMID: 19287319 |  doi: 10.1097/WNR.0b013e328329cbf9
Matsuda W, Furuta T, Nakamura KC, Hioki H, Fujiyama F, Arai R, Kaneko T. (2009) Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum. J Neurosci 29(2):444-53 (January 14).
*About the cover illustration of this issue .
PDF |  PMID: 19144844 |  doi: 10.1523/JNEUROSCI.4029-08.2009
Ide Y, Fujiyama F, Okamoto-Furuta K, Tamamaki N, Kaneko T, Hisatsune T. (2008) Rapid integration of young newborn neurons into a hippocampal circuitry. Eur J Neurosci 28(12):2381-92 (December)
Published online on Dec 9, 2008. |  PDF |  PMID: 19087169 |  doi: 10.1111/j.1460-9568.2008.06548.x
Koshimizu Y, Wu S-X, Unzai T, Hioki H, Sonomura T, Nakamura KC, Fujiyama F, Kaneko T. (2008) Paucity of enkephalin production in neostriatal striosomal neurons: analysis with preproenkephalin/green fluorescent protein transgenic mice. Eur J Neurosci 28(10):2053-64 (November)
*Y. Koshimizu and S-X. Wu contributed equally to this work.
Published online on Nov 6, 2008. |  PDF |  PMID: 19046386 |  doi: 10.1111/j.1460-9568.2008.06502.x
Matsumoto M, Nakagawa T, Kojima K, Sakamoto T, Fujiyama F, Ito J. (2008) Potential of embryonic stem cell-derived neurons for synapse formation with auditory hair cells. J Neurosci Res 86(14):3075-85 (November 1)
Published online on Jun 9, 2008. |  PMID: 18543340 |  doi: 10.1002/jnr.21754
May CA, Nakamura Ko, Fujiyama F, Yanagawa Y. (2008) Quantification and characterization of GABA-ergic amacrine cells in the retina of GAD67-GFP knock-in mice. Acta Ophthalmol 86(4):395-400 (June)
Published online on Nov 7, 2007. |  PMID: 17995983 |  doi: 10.1111/j.1600-0420.2007.01054.x
藤山文乃、金子武嗣 (2007) 大脳基底核の解剖. Clinical Neuroscience 25(1): 22-24
Nakamura Ko, Watakabe A, Hioki H, Fujiyama F, Tanaka Yasuyo, Yamamori T, Kaneko T. (2007) Transiently increased colocalization of vesicular glutamate transporters 1 and 2 at single axon terminals during postnatal development of mouse neocortex: a quantitative analysis with correlation coefficient. Eur J Neurosci 26(11):3054-67 (December)
PDF |  PMID: 18028110 |  Scopus
ERRATUM in 28(5):1032-46, Aug 2008 |  PMID: 18844731 |  doi: 10.1111/j.1460-9568.2008.06449.x
Kuramoto E, Fujiyama F, Unzai T, Nakamura Ko, Hioki H, Furuta T, Shigemoto R, Ferraguti F, Kaneko T. (2007) Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. J Comp Neurol 500(5):908-22 (February 10)
Published Online on December 19, 2006. |  PDF |  PMID: 17177262 |  doi: 10.1002/cne.21216
May CA, Nakamura Ko, Fujiyama F, Komatsu Y, Yanagawa Y. (2007) Homozygous GAD65 and heterozygous GAD67 knock-out mice reveal normal retinal development and maintenance despite reduced amounts of GABA. Acta Neuropathol (Berl) 113(1):101-3 (January)
Published Online on November 7, 2006. |  To get this, go to Acta Neuropathologica. |  PMID: 17089133 |  doi: 10.1007/s00401-006-0157-6
藤山文乃 (2006) 線条体. 脳神経科学イラストレイテッド改訂第2版 88-94
Fujiyama F, Unzai T, Nakamura Ko, Nomura S, Kaneko T. (2006) Difference in Organization of Corticostriatal and Thalamostriatal Synapses between Patch and Matrix Compartments of Rat Neostriatum. Eur J Neurosci 24(10): 2813-24 (November)
Wallen-Mackenzie A, Gezelius H, Thoby-Brisson M, Nygard A, Enjin A, Fujiyama F, Fortin G, Kullander K (2006) Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation. J Neurosci 26(47): 12294-307. (November 22) 
To get this, go to the Journal of Neuroscience |  PMID: 17122055 |  doi: 10.1523/JNEUROSCI.3855-06.2006
藤山 文乃 (2006) 線条体におけるシナプス前性AMPAレセプターの形態学的解析 『顕微鏡』 41(2):90-4.  Review
藤山 文乃 (2005) 線条体出力神経への興奮性入力の形態的解析. ブレインサイエンスレビュー2003 (財)ブレインサイエンス振興財団 伊藤正男 川合述史 編 (医学書院) 219-34.  
Nakamura Ko., Hioki H, Fujiyama F, Kaneko T. (2005) Postnatal changes of vesicular glutamate transporter (VGluT)1 and VGluT2 immunoreactivities and their colocalization in the mouse forebrain. J Comp Neurol 492(3): 263-88. (November 21) 
Published Online on October 10. |  PDF |  PMID: 16217795 |  doi: 10.1002/cne.20705
藤山 文乃、日置 寛之、金子 武嗣 (2005年10月) 中枢神経ネットワークにおけるシナプス小胞性グルタミン酸トランスポーター 『脳21』 8(4): 405-10.  Review
To see this, click here
Tomioka R., Okamoto K., Furuta T., Fujiyama F., Iwasato T., Yanagawa Y., Obata K., Kaneko T., Tamamaki N.. (2005) Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex. Eur J Neurosci 21(6): 1587-600. (March)
PDF |  PMID: 15845086 |  doi: 10.1111/j.1460-9568.2005.03989.x
(Erratum in: Eur J Neurosci. 2005 Apr;21(8):2310.)
Fujiyama F, Kuramoto, E., Okamoto K, Hioki H, Furuta T, Zhou, L., Nomura, S., Kaneko T (2004) Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. Eur J Neurosci 20(12): 3322-30. (December)
PDF |  PMID: 15610164
Hioki H, Fujiyama F, Nakamura Ka, Wu S-X, Matsuda W, Kaneko T. (2004) Chemically specific circuit composed by vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex. Cereb Cortex 14(11): 1266-75.
PDF |  PMID: 15142960
Wu S-X, Koshimizu Y, Fenf Y-P, Okamoto K, Fujiyama F, Hioki H, Li Y-Q, Kaneko T, Mizuno N. (2004) Vesicular glutamate transporter immunoreactivty in the central and peripheral ending of muscle-spindle afferents. Brain Res 1011(2): 247-51.
PDF |  PMID: 15157812
Nakamura Ka, Matsushima K, Hubschle T, Nakamura Y, Hioki H, Fujiyama F, Boldogkoi Z, Konig M, Thiel H-J, Gerstberger R, Kobayashi S, Kaneko T. (2004) Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci 24(23): 5370-80.
PDF |  PMID: 15190110
Nakamura Ka, Wu S-X, Fujiyama F, Okamoto K, Hioki H, Kaneko T. (2004) Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons. Neuroreport 15(3): 431-6.
PDF |  PMID: 15094498
Liu YY, Wong-Riley MT,Liu JP, Wei XY, Jia Y, Liu HL, Fujiyama F, Ju G. (2004) Substance P and enkephalinergic synapses onto neurokinin-1 receptor-immunoreactive neurons in the pre-Botzinger complex of rats. Eur J Neurosci 19(1): 65-75.
PDF |  PMID: 14750964
Lin LH, Edwards RH, Fremeau RTJ, Fujiyama F, Kaneko T, Talman WT. (2004) Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarII. Neuroscience 123(1): 247-55.
PDF |  PMID: 14667459
Collin M, Backberg M, Ovesjo ML, Fisone G, Edwards RH, Fujiyama F, Meister B. (2003) Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur J Neurosci 18(5):1265-78.
PMID: 12956725
Erratum in 18(6):1717.
Oliveira LRA, Hydling F, Olsson E, Shi T, Edwards HR, Fujiyama F, Kaneko T, Hofelt T, Cullheim S, Meister B. (2003) Cellular localization of three vesicular gulutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. Synapse 50(2): 117-29.
PDF |  PMID: 12923814
Fujiyama F, Hioki H, Tomioka R, Taki K, Tamamaki N, Nomura S, Okamoto K, Kaneko T. (2003) Changes of immunocytochemical localization of vesicular glutamate transporters in the rat visual system after the retinofugal denervation. J Comp Neurol 465(2): 234-49.
PDF |  PMID: 12949784
Lin LH, Edwards RH, Fujiyama F. (2003) Vesicular glutamate transporters colocalize with neuronal nitric oxide synthase in rat nucleus tractus solitari. FASEB J 17(5): A888. Part 2 Suppl.S.15.
Lin LH, Agassandian K, Fujiyama F. (2003) Glutamatergic input to preganglionic neurons that effect salivatin, lacrimination, and cerebral vasodilation: exciting a pontine thermoregulatory center. FASEB J 17(4): A25. Part 1 Suppl.S.14
Fujiyama F, Fritschy J-M, Stephenson FA, Bolam JP. (2003) Synaptic localization of GABAA receptor subunits in the basal ganglia of the rat. The Basal Ganglia VI , New York, Kluwer Academic/Plenum Publishers: pp.631-40. Review
Oliveira ALR, Hydling F, Olsson E, Shi T, Edwards RH, Fujiyama F, Kaneko T, Hokfelt T, Cullheim S, Meister B. (2003) Cellular localization off three vesicular glutamate transporter mRNA and proteins in rat spinal cord and dorsal root ganglia. Synapse 50(2): 117-29.
PMID: 12923814
Li J-L, Xiong K-H, Dong Y-L, Fujiyama F, Kaneko T, Mizuno N. (2003) Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to the co-expression. J Comp Neurol 463(2): 212-20.
PDF |  PMID: 12815758
Lin L-H, Agassandian K, Fujiyama F, Kaneko T, Talman WT. (2003) Evidence for a glutamatergic input to pontine preganglionic neurons of the superior salivatory nucleus in rat. J Chem Neuroanat 25(4): 261-8.
PDF |  PMID: 12842271
Hioki H, Fujiyama F, Taki K, Tomioka R, Furuta T, Tamamaki N, Kaneko T. (2003) Differential Distribution of Vesicular Glutamate Transporters in the rat cerebellar Cortex. Neuroscience 117(1): 1-6.
PDF |  PMID: 12605886
Li J-L, Fujiyama F, Kaneko T, Mizuno N. (2003) Expression of Vesicular Glutamate Transporters, VGluT1 and VGluT2, in Axon Terminals of Nociceptive Primary Afferent Fibers in the Superficial Layers of the Medullary and Spinal Dorsal Horns of the Rat. J Comp Neurol 457(3): 236-49.
PDF |  PMID: 12541308
Ichinohe N, Fujiyama F, Kaneko T, Rockland SK. (2003) Honeycomb-Like Mosaic at the Border of Layers 1 and 2 in the Cerebral Cortex. J Neurosci 23(4): 41-8.
PDF |  PMID: 12598625
Liu Y-Y, Wong-Riley, M-T, Liu H-L, Fujiyama F, Ju G. (2003) Relationship between two types of vesicular glutamate and neurokinin-1 receptor-immunoreactive neurons in the pre-Botzinger complex of rats: light and electron microscopic studies. Eur J Neurosci 17(1): 41-8.
PMID: 12534967
Kaneko T, Fujiyama F, Hioki H. (2002) Immunohistochemical Localization of Candidates for Vesicular Glutamate Transporters in the Rat Brain. J Comp Neurol 444(1): 39-62.
PDF |  PMID: 11835181
Kaneko T, Fujiyama F. (2002) Complementary distribution of vesicular glutamate transporters in the central nervous system. Neurosci Res 42(4): 243-50. Review
PDF |  PMID: 11985876
Fujiyama F, Stephenson FA, Bolam JP. (2002) Synaptic localization of GABA(A) receptor subunits in the sybstantia nigra of the rat: effects of quinolinic acid lesions of the striatum. Eur J Neurosci 15(12): 1961-75.
PMID: 12099902
Fujiyama F, Furuta T, Kaneko T. (2001) Immunocytochemical Localization of Candidates for Vesicular Glutamate Transporters in the Rat Cerebral Cortex. J Comp Neurol 435(3): 379-87.
PDF |  PMID: 11406819
Fujiyama F, Fritschy J-M, Stephenson FA, Bolam JP. (2000) Synaptic localization of GABAA receptor subunits in the striatum of the rat. J Comp Neurol 416(2): 158-72.
PMID: 10581463
Fujiyama F, Masuko S. (1996) Association of dopaminergic terminals and neurons releasing nitric oxide in the rat striatum: an electron histochemistru and tyrosine hydroxylase immunohistochemistry. Brain Res Bull 40(2): 121-7.
PMID: 8724430
Masuko S, Fujiyama F (1995) Synapses of cultured neurons isolated from the sustantia nigra. 電子顕微鏡でみるミクロの世界 生物編. 東京 日本電子顕微鏡学会: pp.108-9
Matsuo M, Hamasaki Y, Fujiyama F, Miyazaki S. (1995) Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures. Brain Res. 685(1-2): 201-4.
PMID: 7583247
Kuroda Y, Kurohara K, Fujiyama F, Takashima H, Endo C, Matsui M, Neshige R, Kakigi R. (1992) Systematic interferon-alpha in the treatment of HTLV-1 associated myelopathy. Acta Neurol. Scand. 86(1): 82-6.
PMID: 1519481
Kuroda Y, Kawasaki T, Haraoka S, Fujiyama F, Kakigi R, Abe M, Tabuchi K, Kuroiwa T, Kishikawa T, Sugihara H. (1992) Autopsy report of primary CNS B-cell lymphoma indistingnishable from multiple sclerosis: diagnosis with the immunoglobulin gene rearrangements analysis. J. Neurol. Sci. 111(2): 173-9.
PMID: 1431983
Kuroda Y, Fujiyama F, Ohyma T, Watanabe T, Endo C, Neshige R, Kakigi R. (1991) Numb chin syndrome secondary to Burkitt's cell acute leukemia. Neurology 41(3): 453-4
PMID: 2006020
Neshige R, Kuroda Y, Kakigi R, Fujiyama F, Matoba R, Yarita M, Luders H, Shibasaki H. (1991) Event-related brain potentials as indicators of visual recognition and detection of criminals by their use. Forensic Sci Int 51(1): 95-103.
 PMID: 1752597
Kuroda Y, Fujiyama F, Nagumo F. (1991) Analysis of factors of relevance to rapid clinical progression in HTLV-1-associated myelopathy. J Neurol Sci 105(1): 61-6.
PMID: 1795171
Neshige R, Kuroda Y, Kakigi R, Fujiyama F, Yarita M. (1991) Task-irrelevant potentials related to recognition of photograph. Jpn J EEG and EMG 19(1): 25-31.
Fujiyama F, Kuroda Y, Shibasaki H. (1991) Diagnosis and treatment of multiple sclerosis. 多発性硬化症 Clinical and Exprerimental Medicine 臨床と研究 別冊 4: 37-42.
Fujiyama F, Matsuzaki M, Shimamoto Y, Noguchi T, Kurata Y, Kuroda Y, Yamaguchi M. (1991) Burkitt's type ALL with Numb chin syndrome as initial manifestation. Jpn Rinsho Ketsueki 32(2):152-5.
PMID: 2027241

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