Publication in Morphological Brain Science 


Numbers indicate the serial numbers of original articles, and ‘R-’points to review articles. Partially in Japanese.

You can get the PDF file from inside of the Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University (You need the ID and password). Otherwise please go to the PubMed site.


1) Local Neural Circuit in the Central Nervous System (CNS)

1-1) Local circuit in the cerebral cortex

155. Cho R.-H., Segawa S., Okamoto K., Mizuno A., Kaneko T., Intracellularly labeled pyramidal neurons in hte cortical areas projecting to the spinal cord. II. Intra- and juxta-columnar projection of pyramidal neurons to corticospinal neurons. Neuroscience Research, vol. 40 (no. 4), pp. 395-410, December, 2004 (online; October 20). To get this, click pdf-33.jpg. To see the abstract, go to the PubMed (15567477). PhD (Nagasaki U) paper of Dr. Cho.

154. Cho R.-H., Segawa S., Mizuno A., Kaneko T., Intracellularly labeled pyramidal neurons in the cortical areas projecting to the spinal cord. I. Electrophysiological properties of pyramidal neurons. Neuroscience Research, vol. 40 (no. 4), pp. 381-394, December, 2004 (online; October 20). To get this, click pdf-32.jpg. To see the abstract, go to the PubMed (15567476). PhD (Nagasaki U) paper of Dr. Cho.

153. Hioki H., Fujiyama F., Nakamura Ko., Wu S.-X., Matsuda W., Kaneko T., Chemically specific circuit composed by vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex. Cerebral Cortex, vol. 14 (no. 11), pp. 1266-1275, November, 2004 (online; May 13). To get this, click pdf-31.jpg. To see the abstract, go to the PubMed (15142960).  PhD paper of Dr. H. Hioki.

R-14. Kaneko T., Local Circuit in the Cerebral Cortex. In The Neural Basis of Early Vision ( Keio University International Symposia for Life Science and Medicine 11), pp.71-72, Springer, 2003.

R-11. 金子武嗣, 大脳皮質の神経回路, In: 脳の情報表現 ニューロン・ネットワーク・数理のモデル (銅谷賢治、伊藤浩之、藤井宏、塚田稔 編集),pp. 131-145, 朝倉書店、東京、2002.3.20

R-10. 金子武嗣, 大脳皮質の局所神経回路, In: ブレインサイエンスレビュー (伊藤正男、川合述史 編集), pp. 170-183, 医学書院, 東京, 2001

101. Kaneko T., Cho R.-H., Li Y.-Q., Nomura S., Mizuno N., Predominant information transfer from layer III pyramidal neurons to corticospinal neurons. The Journal of Comparative Neurology, vol. 423 (no. 1), pp. 52-65, July 17, 2000. To get this, click pdf-27-1.jpg. To see the abstract, go to the PubMed.

100. Taki K., Kaneko T., Mizuno N., A group of cortical interneurons expressing mu-opioid receptor-like immunoreactivity: a double immunofluorescence study in the rat cerebral cortex. Neuroscience, vol. 98 (no. 2), pp. 221-231, June, 2000. To get this, click pdf-27.jpg. To see the abstract, go to the PubMed. PhD paper of Dr. Taki.

R-8. 金子武嗣, 大脳皮質の神経回路, Equilibrium Research, vol. 59(3), pp. 178-185, 2000.

88. Kan Y., Endo K., Araki T., Kaneko T., Trans-synaptically induced bursts in regular spiking non-pyramidal cells in deep layers of the cat motor cortex. Cerebral Cortex, vol. 9 (no. 1), pp. 77-89, January/ February, 1999. To get this, click pdf-16.jpg. To see the abstract, 

84. Kaneko T., Murashima M., Lee T., Mizuno N., Characterization of neocortical non-pyramidal neurons expressing preprotachykinins A and B: A double immunofluorescence study in the rat. Neuroscience, vol. 86 (no. 3), pp. 765-781, June 8, 1998. To get this, click pdf-13-2.jpg. To see the abstract, go to the PubMed.

80. Caria M. A., Kaneko T., Kimura A., Asanuma H., Functional organization of the projection from area 2 to area 4g in the cat. Journal of Neurophysiology, vol. 77 (no. 6), pp. 3107-3114, June, 1997. To see the abstract, go to the PubMed.

63. Kaneko T., Kang Y., Mizuno N., Glutaminase-positive and glutaminase-negative pyramidal cells in layer VI of the primary and somatosensory cortices: A combined analysis by intracellular staining and immunocytochemistry in the rat. The Journal of Neuroscience, vol. 15 (no. 12), pp. 8362-8377, December, 1995. To see the abstract, go to the PubMed.

52. Kaneko T., Caria M. A., Asanuma H., Information processing within the motor cortex. II. Intracortical connections between neurons receiving somatosensory cortical input and motor output neurons of the cortex. The Journal of Comparative Neurology, vol. 345 (no. 2), pp. 172-184, July 8, 1994. To see the abstract, go to the PubMed.

51. Kaneko T., Caria M. A., Asanuma H., Information processing within the motor cortex. I. Responses of morphologically identified motor cortical cells to stimulation of the somatosensory cortex. The Journal of Comparative Neurology, vol. 345 (no. 2), pp. 161-171, July 8, 1994. To see the abstract, go to the PubMed.

50. Kang Y., Kaneko T., Ohishi H., Endo K., Araki T., Spatiotemporally differential inhibition of pyramidal cells in the rat motor cortex. Journal of Neurophysiology, vol. 71 (no. 1), pp. 280-293, January, 1994. To see the abstract, go to the PubMed.


1-2) Local circuit in the striatum

172. Fujiyama F, Unzai T, Nakamura Ko, Nomura S, Kaneko T, Difference in organization of corticostriatal and thalamostriatal synapses between patch and matrix compartments of rat neostriatum. European Journal of Neuroscience, vol. 24 (no. 10), pp. 2813-1824, November, 2006. To get this, click pdf-2-1.jpg. To see the abstract, go to the PubMed (17156206).

157. Fujiyama F., Kuramoto E., Okamoto K., Hioki H., Furuta T., Zhou L., Nomura S., Kaneko T., Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. European Journal of Neuroscience, vol. 20 (no. 12), pp. 3322-3330, December, 2004 (online; December 9). To get this, click pdf-35.jpg. To see the abstract, go to the PubMed (15610164).

97. Li J.-L., Wang D., Kaneko T., Shigemoto R., Nomura S., Mizuno N., Relationship between neurokinin-1 receptor and substance P in the striatum: light and electron microscopic immunohistochemical study in the rat. The Journal of Comparative Neurology, vol. 418 (no. 2), pp. 156-163, March 6, 2000. To get this, click pdf-24.jpg. To see the abstract, go to the PubMed.

83. Lee T., Kaneko T., Shigemoto R., Mizuno N., Collateral projections from striatonigral neurons to substance P receptor-expressing intrinsic neurons in the striatum of the rat. The Journal of Comparative Neurology, vol. 388 (no. 2), pp. 250-264, November 17, 1997. To get this, click pdf-13-1.jpg. To see the abstract, go to the PubMed.

84. Kaneko T., Murashima M., Lee T., Mizuno N., Characterization of neocortical non-


2) Computational Approach to Cortical Circuit

188.  Tanaka T, Kaneko T, Aoyagi T, Recurrent infomax generates cell assemblies, neuronal avalanches, and simple cell-like selectivity.  Neural Computation, vol 21 (no 4), pp 1038-1067, April, 2009 (online, October 17, 2008; posted online, March 20, 2009). To get this, click pdf-9-1-1-1-1-1-1.jpg.  To see the abstract, go to the PubMed (18928369). PhD paper of Dr. T. Tanaka.

148. Tsubo Y., Kaneko T., Shinomoto S., Predicting spike timings of current-injected neurons. Neural Networks, vol. 17 (no.2), pp. 165-173, March, 2004 (online; December 29, 2003). To get this, click pdf-28-45.jpg. To see the abstract, go to the PubMed.

132. Aoyagi T., Kang Y., Terada N., Kaneko T., Fukai T., The role of Ca2+-dependent cationic current in generating gamma frequency rhythmic bursts: modeling study. Neuroscience, vol. 115 (no. 4), pp. 1127-1138, December 16, 2002. To get this, click pdf-28-29.jpg. To see the abstract, go to the PubMed.


3) Tools for the Morphological Study of the CNS

195.  Tanahira C, Higo S, Watanabe K, Tomioka R, Ebihara S, Kaneko T, Tamamaki N. Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice.  Neuroscience Research, vol 63 (no 3), pp 213-223, March, 2009 (online, January 9). To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1-1.jpg.  To see the abstract, go to PubMed (19167436).

191.  Hioki H, Kuramoto E, Konno M, Kameda H, Takahashi Y, Nakano T, Nakamura KC, Kaneko T.  High-level transgene expression in neurons by lentivirus with Tet-Off system.  Neuroscience Research, vol. 63 (no. 2): 149-154, February, 2009 (online, November 6, 2008). To get this, click pdf-9-1-1-1-1-1-2-2.jpg.  To see the abstract, go to PubMed (19028532).

189.  Koshimizu Y, Wu S-H, Unzai T, Hioki H, Sonomura T, Nakamura KC, Fumino Fujiyama F, Kaneko T, Paucity of enkephalin production in neostriatal striosomal neurons: Analysis with preproenkephalin/green fluorescent protein transgenic mice.  European Journal of Neuroscience, vol. 28 (no. 10): 2053-2064, November, 2008 (online, November 6).   To get this, click pdf-9-1-1-1-1-1-2.jpg.  To see the abstract, go to PubMed (19046386).

186. Nakamura KC, Kameda H, Koshimizu Y, Yanagawa Y, Kaneko T,  Production and histological application of affinity-purified antibodies to heat-denatured green fluorescent protein.  Journal of Histochemistry & Cytochemistry, vol. 56 (no. 7), pp. 647-657, July, 2008 (online, April 14).  To get this, click pdf-9-1-1-1-1.jpg.  To see the abstract, go to the PubMed (18413647).

185. Tanaka Yasuyo, Tanaka Yasuhiro, Furuta T, Yanagawa Y, Kaneko T, The Effects of cutting solutions on the viability of GABAergic interneurons in cerebral cortical slices of adult mice.  Journal of Neuroscience Methods, vol. 171 (no. 1), pp. 118-125, June 15, 2008 (online, March 13).  To get this, click pdf-9-1-2-1-1-1.jpg.  To see the abstract, go to the PubMed (18430473).

183. Kameda H, Furuta T, Matsuda W, Ohira K, Nakamura Ko, Hioki H, Kaneko T, Targeting green fluorescent protein to dendritic membrane in central neurons. Neuroscience Research, vol. 61 (no. 1), pp. 79-91, May, 2008 (online, February 6).   To get this, click pdf-9-1-2-1.jpg.  To see the abstract, go to the PubMed (18342383).

176. Hioki H, Kameda H, Nakamura H, Okunomiya T, Ohira K, Nakamura Ko, Kuroda M, Furuta T, Kaneko T, Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters. Gene Therapy, vol. 14 (no. 11), pp. 872-882, June, 2007 (online, March 15). To get this, click pdf-6-1.jpg. To see the abstract, go to the PubMed (17361216).

146. Tamamaki N., Yanagawa Y., Tomioka R., Miyazaki J., Obata K., Kaneko T., Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. The Journal of Comparative Neurology, vol. 467(no. 1), pp.60-79, December 1, 2003. To get this, click pdf-28-43.jpg. To see the abstract, go to the PubMed.

R-15. 中西重忠, 藤沢肇, 金子武嗣, 丹治順, 大森治紀, 澁木克栄, 野田亮, 山森哲雄, 神経回路形成研究の現状と今後の展望、In: 蛋白質 核酸 酵素 20038月増刊号 Vol.48 (no.11) 化学と生物学の接点がつくるNewバイオテクノロジー(多比良和誠、管祐明 編集)、pp.205-225, 共立出版、東京、2003.8.10

R-13. 金子武嗣, 脳の局所神経回路ー遺伝子工学を用いての脳の設計図を探るー. 学術月報 vol. 56 (no. 4), pp.12-18, April 152003.

123. Furuta.T., Tomioka R., Taki K., Nakamura K., Tamamaki N., Kaneko T., In Vivo Transduction of central neurons using recombinant Sindbis virus: Golgi-like labeling of dendrites and axons with membrance-targeted fluorescent proteins. The Journal of Histochemistry & Cytochemistry, vol. 49 (no. 12), pp.1497-1507, December, 2001. To get this, click pdf-28-20.jpg. To see the abstract, go to the PubMed.

107. Tamamaki N., Nakamura K., Furuta T., Asamoto K., and Kaneko, T., Neurons in Golgi-stain-like images revealed by GFP-adenovirus infection in vivo. Neuroscience Research, vol. 38 (no. 3), pp. 231-236, November, 2000. To get this, click pdf-28-5.jpg. To see the abstract, go to the PubMed.

67. Kaneko T., Saeki K., Lee T., Mizuno N., Improved retrograde axonal transport and subsequent visualization of tetramethylrhodamine (TMR)-dextran amine by means of an acidic injection vehicle and antibodies against TMR. Journal of Neuroscience Methods, vol. 65 (no. 2), pp. 157-165, April, 1996. To get this, click pdf-5.jpg. To see the abstract, go to the PubMed.

21. Kaneko T., Urade Y., Mizuno N., Correlation between immunochemical characteristics and immunohistochemical applicability of nine lines of monoclonal antibodies against rat brain glutaminase. The Journal of Histochemistry and Cytochemistry, vol. 36 (no. 8), pp. 997-1004, August, 1988. To see the abstract, go to the PubMed.


4) Neural Circuit and Chemical Characteristics of the CNS

4-1) Cerebral Cortex and Thalamus

198. Furuta T, Kaneko T, Deschênes M. Septal neurons in barrel cortex derive their receptive field input from the lemniscal pathway. The Journal of Neuroscience, vol 29 (no 23), pp 4089-4095, April 1, 2009.  To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1-1-1-1-1.jpg.  To see the abstract, go to PubMed (19339604).

197.  Yoshida M, Satoh T, Nakamura KC, Kaneko T, Hata Y.  Activity-dependent regulation of corticothalamic synapses in dorsal lateral geniculate nucleus of rats. Neuroscience Research, vol 64 (no 1), May, 2009 (online, February 13).  To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1-1-1-1.jpg.  To see the abstract, go to PubMed (19428690).

193.  Kuramoto E, Furuta T, Nakamura KC, Unzai T, Hioki H, Kaneko T.  Two types of thalamocortical projections from the motor thalamic nuclei of the rat: A single neuron tracing study using viral vectors.  Cerebral Cortex, vo. 19 (no. 9), pp. 2065-2077, September, 2009 (online, January 27).  To get this, click pdf-9-1-1-1-1-1-2-1-1-1.jpg.  To see the abstract, go to PubMed (19174446).  PhD paper of Dr. E. Kuramoto.

159. Tomioka R., Okamoto K., Furuta T., Fujiyama F., Iwasato T., Yanagawa Y., Obata K., Kaneko T., Tamamaki N., Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex. European Journal of Neuroscience, vol. 21 (no. 6), pp. 1587-1600, March, 2005 (online; April 12). To get this, click pdf-37.jpg. To see the abstract, go to the PubMed (15845086). PhD paper of Dr. Tomioka.

153. Hioki H., Fujiyama F., Nakamura Ko., Wu S.-X., Matsuda W., Kaneko T., Chemically specific circuit composed by vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex. Cerebral Cortex, vol. 14 (no. 11), pp. 1266-1275, November, 2004 (online; May 13). To get this, click pdf-31-1.jpg. To see the abstract, go to the PubMed (15142960).  PhD paper of Dr. H. Hioki.

146. Tamamaki N., Yanagawa Y., Tomioka R., Miyazaki J., Obata K., Kaneko T., Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. The Journal of Comparative Neurology, vol. 467(no. 1), pp.60-79, December 1, 2003. To get this, click pdf-28-43-1.jpg. To see the abstract, go to the PubMed.

115. Fujiyama F., Furuta T., Kaneko T., Immunocytochemical localization of candidates for vesicular glutamate transporters in the rat cerebral cortex. The Journal of Comparative Neurology, vol. 435 (no. 3), pp. 379-387, July 2, 2001. To get this, clickpdf-28-13.jpg . To see the abstract, go to the PubMed.

100. Taki K., Kaneko T., Mizuno N., A group of cortical interneurons expressing mu-opioid receptor-like immunoreactivity: a double immunofluorescence study in the rat cerebral cortex. Neuroscience, vol. 98 (no. 2), pp. 221-231, June, 2000. To get this, click pdf-27-2.jpg. To see the abstract, go to the PubMed. PhD paper of Dr. Taki.

84. Kaneko T., Murashima M., Lee T., Mizuno N., Characterization of neocortical non-pyramidal neurons expressing preprotachykinins A and B: A double immunofluorescence study in the rat. Neuroscience, vol. 86 (no. 3), pp. 765-781, June 8, 1998. To get this, click pdf-13-2-1.jpg. To see the abstract, go to the PubMed.

75. Kaneko T. and Mizuno N., Spiny stellate neurones in layer VI of the rat cerebral cortex. NeuroReport, vol. 7 (no. 14), pp. 2331-2335, October 2, 1996. To see the abstract, go to the PubMed.

63. Kaneko T., Kang Y., Mizuno N., Glutaminase-positive and glutaminase-negative pyramidal cells in layer VI of the primary and somatosensory cortices: A combined analysis by intracellular staining and immunocytochemistry in the rat. The Journal of Neuroscience, vol. 15 (no. 12), pp. 8362-8377, December, 1995. To see the abstract, go to the PubMed.

48. Kaneko T., Shigemoto R., Nakanishi S., Mizuno N., Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons. Brain Research vol. 631 (no. 2), pp. 297-303, December 24, 1993. To see the abstract, go to the PubMed.

40. Kaneko T., Nakaya Y., Mizuno N., Paucity of glutaminase-immunoreactive nonpyramidal neurons in the rat cerebral cortex. The Journal of Comparative Neurology, vol. 322 (no. 2), pp. 181-190, August 8, 1992. To see the abstract, go to the PubMed.

30. Akiyama H., Kaneko T., Mizuno N. and McGeer P. L., Distribution of phosphate-activated glutaminase in the human cerebral cortex. The Journal of Comparative Neurology, vol. 297 (no. 2), pp. 239-252, July 8, 1990. To see the abstract, go to the PubMed.

26. Akiyama H., McGeer P. L., Itagaki S., McGeer E. G. and Kaneko T., Loss of glutaminase-positive cortical neurons in Alzheimer's disease. Neurochemical Research, vol. 14 (no. 4), pp. 353-358, April, 1989. To see the abstract, go to the PubMed.

19. Kaneko T., Mizuno N., Immunohistochemical study of glutaminase-containing neurons in the cerebral cortex and thalamus of the rat. The Journal of Comparative Neurology, vol. 267 (no. 4), pp. 590-602, January 22, 1988. To see the abstract, go to the PubMed. PhD paper of Dr. Kaneko.

13. Kaneko T., Tashiro K., Sugimoto T., Konishi A., Mizuno N., Identification of vasoactive intestinal polypeptide-like immunoreactive neurons in the rat thalamus. Brain Research, vol. 347 (no. 2), pp. 390-393, November 18, 1985. To see the abstract, go to the PubMed.


4-2) Basal ganglia

194.  Matsuda W, Furuta T, Nakamura KC, Hioki H, Fujiyama F, Arai R, Kaneko T. Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum.  The Journal of Neuroscience, vol. 29 (no. 2): 444-453, January 14, 2009 (online, January 14). To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1.jpg.  To see the abstract, go to PubMed (19144844).  PhD paper of Dr. W. Matsuda.

189.  Koshimizu Y, Wu S-H, Unzai T, Hioki H, Sonomura T, Nakamura KC, Fumino Fujiyama F, Kaneko T, Paucity of enkephalin production in neostriatal striosomal neurons: Analysis with preproenkephalin/green fluorescent protein transgenic mice.  European Journal of Neuroscience, vol. 28 (no. 10): 2053-2064, November, 2008 (online, November 6).   To get this, click pdf-9-1-1-1-1-1-2-1.jpg.  To see the abstract, go to PubMed (19046386).

179. Sonomura T, Nakamura Ko, Furuta T, Hioki H, Nishi A, Yamanaka A, Uemura M, Kaneko T, Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B. European Journal of Neuroscience, , vol. 26 (no. 8), pp. 3093-3103, December, 2007. (online, November 16). To get this, click pdf-9-1.jpg. To see the abstract, go to the PubMed (18028111). PhD (Kagoshima U) paper of Dr. T Sonomura.

173. Kuramoto E, Fujiyama F, Unzai T, Nakamura Ko, Hioki H, Furuta T, Shigemoto R, Ferraguti F, Kaneko T, Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. The Journal of Comparative Neurology, vol. 500 (no. 5), pp. 908-922, February 10, 2007 (online; December 19, 2006). To get this, click pdf-3-1-1.jpg. To see the abstract, go to the PubMed (17177262).

172. Fujiyama F, Unzai T, Nakamura Ko, Nomura S, Kaneko T, Difference in organization of corticostriatal and thalamostriatal synapses between patch and matrix compartments of rat neostriatum. European Journal of Neuroscience, vol. 24 (no. 10), pp. 2813-1824, November, 2006. To get this, click pdf-2-1-1.jpg. To see the abstract, go to the PubMed (17156206).

157. Fujiyama F., Kuramoto E., Okamoto K., Hioki H., Furuta T., Zhou L., Nomura S., Kaneko T., Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. European Journal of Neuroscience, vol. 20 (no. 12), pp. 3322-3330, December, 2004 (online; December 9). To get this, click pdf-35-1.jpg. To see the abstract, go to the PubMed (15610164).

156. Zhou L., Furuta T., Kaneko T., Neurokinin B-producing projection neurons in the lateral stripe of the striatum and cell clusters of the accumbens nucleus in the rat. The Journal of Comparative Neurology, vol. 480 (no. 2), pp. 143-161, December 6, 2004 (online; October 28). To get this, click pdf-34.jpg. To see the abstract, go to the PubMed (15514933).

150. Furuta T., Koyano K., Tomioka R., Yanagawa Y., Kaneko T., GABAergic basal forebrain neurons which express receptor for neurokinin B and send axons to the cerebral cortex. The Journal of Comparative Neurology, vol. 473 (no.1) , pp. 43-58, May 17, 2004 (online; March 30). To get this, click pdf-28-47.jpg. To see the abstract, go to the PubMed (15067717).

140. Zhou L., Furuta T., Kaneko T., Chemical organization of projection neurons in the rat accumbens nucleus and olfactory tubercle. Neuroscience, vol. 120 (no.3), pp. 783-798, September 1, 2003. To get this, click pdf-28-37.jpg. To see the abstract, go to the PubMed. PhD paper of Dr. Zhou.

131. Furuta T., Zhou L., Kaneko T., Preprodynorphin-, preproenkephalin-, preprotachykinin A- and preprotachykinin B-immunoreactive neurons in the accumbens nucleus and olfactory tobercle: Double- immunofluorescence analysis. Neuroscience, vol. 114 (no. 3), pp. 611-627, October 11, 2002. To get this, clickpdf-28-28.jpg . To see the abstract, go to the PubMed.

128. Li J.-L., Kaneko T., Mizuno N., Synaptic association of dopaminergic axon terminals and neurokinin-1 receptor-expressing intrinsic neurons in the striatum of the rat. Neuroscience Letters, vol. 324 (no. 1), pp. 9-12, May 10, 2002. To get this, click pdf-28-25.jpg. To see the abstract, go to the PubMed.

126. Li J.-L., Dong Y.-L., Kaneko T., Mizuno N., Direct projections from substance P-containing neurons to nitric oxide synthase-containing interneurons in the rat striatum. Neuroscience Letters, vol.318 (no. 3), pp. 133-136, February 1, 2002. To get this, click pdf-28-23.jpg. To see the abstract, go to the PubMed.

111. Li Y.-Q., Kaneko T., Mizuno N., Collateral projections of nucleus raphe dorsalis neurones to the caudate-putamen and region around the nucleus raphe magnus and nucleus reticularis gigantocellularis pars α in the rat. Neuroscience Letters, vol. 299 (no. 1-2), pp. 33-36, February 16, 2001. To get this, click pdf-28-9.jpg. To see the abstract, go to the PubMed.

106. Furuta T., Mori T., Lee T., Kaneko T., Third group of neostriatofugal neurons: neurokinin B-producing neurons that send axons predominantly to the substantia innominata. The Journal of Comparative Neurology, vol. 426 (no. 2), pp. 279-296, October 16, 2000. To get this, click pdf-28-4.jpg. To see the abstract, go to the PubMed.

82. Lee T., Kaneko T., Taki K., Mizuno N., Preprodynorphin-, preproenkephalin-, and preprotachykinin-expressing neurons in the rat neostriatum: An analysis by immunocytochemistry and retrograde tracing. The Journal of Comparative Neurology, vol. 386 (no. 2), pp. 229-244, September 22, 1997. To get this, click pdf-13.jpg. To see the abstract, go to the PubMed. PhD paper of Dr. Lee.

48. Kaneko T., Shigemoto R., Nakanishi S., Mizuno N., Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons. Brain Research vol. 631 (no. 2), pp. 297-303, December 24, 1993. To see the abstract, go to the PubMed.

43. Shigemoto R., Nakaya Y., Nomura S., Ogawa-Meguro R., Ohishi H., Kaneko T., Nakanishi S. and Mizuno N., Immunocytochemical localization of rat substance P receptor in the striatum. Neuroscience Letters, vol. 153 (no. 2), pp. 157-160, April 30, 1993. To see the abstract, go to the PubMed.

38. Kaneko T., Mizuno N., Mosaic distribution of phosphate-activated glutaminase-like immunoreactivity in the rat neostriatum. Neuroscience, vol. 49 (no. 2), pp. 329-345, 1992. To see the abstract, go to the PubMed.


4-3) Trigeminal system, spinal dorsal horn and pain

190.  Pang Y-W, Ge S-N, Nakamura KC, Li  J-L, Xiong K-H, Kaneko T, Mizuno N.  Axon terminals expressing vesicular glutamate transporter VGLUT1 or VGLUT2 within the trigeminal motor nucleus of the rat: origins and distribution patterns.  The Journal of Comparative Neurology, vol. 512 (no. 5): 595-612, February 10, 2009 (online, December 4, 2008).  To get this, click pdf-9-1-1-1-1-1-2-1-1.jpg.  To see the abstract, go to PubMed (19058187, 19086052, 19097020).

180. Furuta T, Timofeeva E, Nakamura Ko, Okamoto K, Kaneko T, Deschenes M, Inhibitory gating of vibrissal inputs in the brainstem. The Journal of Neuroscience, vol. 28 (no. 8), pp. 1789-1797, February 20, 2008 (online, January 30).  To get this, click pdf-9-1-1.jpg. To see the abstract, go to the PubMed (18287495).

170. Li J-L, Xiong K, Pang Y-W, Dong Y, Kaneko T, Mizuno N, Medullary dorsal horn neurons providing axons both to the parabrachial nucleus and the thalamus. The Journal of Comparative Neurology, vol. 498 (no. 4), pp. 539-551, July 27, 2006. To get this, click pdf-47.jpg. To see the abstract, go to the PubMed (16874804).

169. Pang Y-W, Li J-L, Nakamura Ko, Wu S, Kaneko T, Mizuno N, Expression of vesicular glutamate transporter VGLUT1 immunoreactivity in peripheral and central endings of trigeminal mesencephalic nucleus neurons in the rat. The Journal of Comparative Neurology, vol. 498 (no. 1), pp.129-141, July 19, 2006. To get this, click pdf-46.jpg. To see the abstract, go to the PubMed (16856164).

158. Li J.-L., Tomioka R., Okamoto K., Nakamura Ko., Wu S.-X., Kaneko T., Mizuno N., Efferent and afferent connections of GABAergic neurons in the supratrigeminal and the intertrigeminal regions. An immunohistochemical tract-tracing study in the GAD67-GFP knock-in mouse. Neuroscience Research, vol. 51 (no. 1), pp. 81-91, January, 2005 (online; December 2). To get this, click pdf-36.jpg. To see the abstract, go to the PubMed (15596244).

139. Li J.-L., Xiong K.-H., Dong Y.-L., Fujiyama F., Kaneko T., Mizuno N., Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to the co-expression. The Journal of Comparative Neurology, vol. 463 (no.2), pp. 212-220, August 18, 2003. To get this, click pdf-28-36.jpg. To see the abstract, go to the PubMed.

135. Li J-L., Fujiyama F., Kaneko T., Mizuno N., Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat. The Journal of Comparative Neurology, vol. 457 (no. 3), pp. 236-249, March 10, 2003. To get this, click pdf-28-32.jpg. To see the abstract, go to the PubMed.

121. Li J.-L., Li Y.-Q., Nomura S., Kaneko T., Mizuno N., Protein kinase C gamma-like immunoreactiveity in the substantia gelatinosa of the medullary dorsal horn of the rat. Neuroscience Letters, vol. 311 (no. 3), pp. 185-188, October 5, 2001. To get this, click pdf-28-18.jpg. To see the abstract, go to the PubMed.

117. Li Y.-Q., Li J.-L., Li H., Kaneko T., Mizuno N., Protein kinase C gamma-like immunoreactivity of trigeminothalamic neurons in the medullary dorsal horn of the rat. Brain Research, vol. 913 (no. 2), pp. 159-164, September 21, 2001. To get this, click pdf-28-15.jpg. To see the abstract, go to the PubMed.

109. Li Y.-Q., Li H., Yang K., Wang Z.-M., Kaneko T., Mizino N., Intracellular labeling study of neurons in the superficial part of the magnocellular layer of the medullary dorsal horn of the rat. The Journal of Comparative Neurology, vol. 428 (no. 4), pp. 641-655, December 25, 2000. To get this, click pdf-28-7.jpg. To see the abstract, go to the PubMed.

105. Li Y.-Q., Li H., Yang K., Kaneko T., Mizuno N., Morphologic features and electrical membrane properties of projection neurons in the marginal layer of the medullary dorsal horn of the rat. The Journal of Comparative Neurology, vol. 424 (no. 1), pp. 24-36, August 14, 2000. To get this, click pdf-28-3.jpg. To see the abstract, go to the PubMed.

103. Li Y.-Q., Wu S.-X., Li J.-L., Li J.-S., Kaneko T., and Mizuno N., Co-existence of calcium-binding proteins in neurons of the medullary dorsal horn of the rat. Neuroscience Letters, vol. 286 (no. 2), pp. 103-106, June 2, 2000. To get this, click pdf-28-1.jpg. To see the abstract, go to the PubMed.

102. Li J.-L., Xiong K.-H., Li Y.-Q., Kaneko T., Mizuno N., Serotonergic innervation of mesencephalic trigeminal nucleus neurons: a light and electron microscopic study in the rat. Neuroscience Research, vol. 37 (no. 2) , pp. 127-140, June, 2000. To get this, click pdf-28.jpg. To see the abstract, go to the PubMed.

99. Li J.-L., Wang D., Kaneko T., Shigemoto R., Nomura S., Mizuno N., The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research, vol. 36 (no. 4), pp. 327-334, April, 2000. To get this, click pdf-26.jpg. To see the abstract, go to the PubMed.

95. Li J.-L., Li Y.-Q., Li J.-S., Kaneko T., and Mizuno N., Calcium-binding protein-immunoreactive projection neurons in the caudal subnucleus of the spinal trigeminal nucleus of the rat. Neuroscience Research, vol. 35 (no. 3), pp. 225-240, December 1, 1999. To get this, click pdf-22.jpg. To see the abstract, go to the PubMed.

93. Li Y.-Q., Li H., Kaneko T., Mizuno N., Local circuit neurons showing calbindin D28k-immunoreactivity in the substantia gelatinosa of the medullary dorsal horn of the rat. An immunohistochemical study combined with intracellular staining in slice preparation. Brain Research, vol. 840 (no.1-2), pp. 179-183, September 4, 1999. To get this, click pdf-21.jpg. To see the abstract, go to the PubMed.

92. Li Y.-Q., Li H., Kaneko T., Mizuno N., Substantia gelatinosa neurons in the medullary dorsal horn: an intracellular labeling study in the rat. The Journal of Comparative Neurology, vol. 411(no.3), pp. 399-412, August 30, 1999. To get this, click pdf-20.jpg. To see the abstract, go to the PubMed.

91. Ding Y.-Q., Zheng H.-X., Wang D.-S., Xu J.-Q., Gong L.-W., Lu Y., Qin B.-Z., Shi J., Li H.-L., Li J.-S., Shigemoto R., Kaneko T., Mizuno, N., The distribution of substance P receptor (NK1)-like immunoreactive neurons in the newborn and adult human spinal cord. Neuroscience Letters, vol. 266 (no.2), pp. 133-136, May 7, 1999. To get this, click pdf-19.jpg. To see the abstract, go to the PubMed.

90. Li J.-L., Li Y.-Q., Keneko T., Mizuno N., Preprodynorphin-like immunoreactivity in medullary dorsal horn neurons projecting to the thalamic regions in the rat. Neuroscience Letters, vol. 264 (no.1-3), pp. 13-16, April 2, 1999. To get this, click pdf-18.jpg. To see the abstract, go to the PubMed.

86. Li J.-L., Kaneko T., Nomura S., Mizuno N., Projections from the caudal spinal trigeminal nucleus to commissural interneurons in the spratrigeminal region: an electron microscope study in the rat. Neuroscience Letters, vol. 254 (no. 1), pp. 57-60, September 18, 1998. To get this, click pdf-14.jpg. To see the abstract, go to the PubMed.

85. Li J.-L., Ding Y.-Q., Li Y.-Q., Li J.-S., Nomura N., Kankeo T., Mizuno N., Immunocytochemical localization of μ-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide. A light and electron microscope study in the rat. Brain Research, vol. 794 (no. 2), pp. 347-352, June 1, 1998. To get this, click pdf-13-3.jpg. To see the abstract, go to the PubMed.

79. Li J.-L., Kaneko T., Nomura S., Li Y-Q., Mizuno N, Association of serotonin-like immunoreactive axons with nociceptive projection neurons in the caudal spinal trigeminal nucleus of the rat. The Journal of Comparative Neurology, vol. 384 (no. 1), pp. 127-141, July 21, 1997. To get this, click pdf-12.jpg. To see the abstract, go to the PubMed.

78. Gong L.-W., Ding Y.-Q., Wang D., Zheng H.-X., Qin B.-Z., Li J.-S., Kaneko T., Mizuno N., GABAergic synapses on μ-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord. Neuroscience Letters vol. 227 (no. 1), pp. 33-36, May 9, 1997. To get this, click pdf-11.jpg. To see the abstract, go to the PubMed.

77. Li J.-L., Kaneko T., Shigemoto R., Mizuno N., Distribution of trigeminohypothalamic and aspinohypothalamic tract neurons displaying substance P-like immunoreactivity in the rat. The Journal of Comparative Neurology, vol. 378 (no. 4), pp. 508-521, February 24, 1997. To get this, click pdf-10.jpg. To see the abstract, go to the PubMed.

76. Li Y.-Q., Takada M., Kaneko T., Mizuno N., Distribution of GABAergic and glycinergic premotor neurons projecting to the facial and hypoglossal nuclei in the rat. The Journal of Comparative Neurology, vol. 378 (no. 2), pp. 283-294, February 10, 1997. To get this, click pdf-9.jpg. To see the abstract, go to the PubMed.

73. Li Y.-Q., Takada M., Kaneko T., Mizuno N., GABAergic and glycinergic neurons projecting to the trigeminal motor nucleus: a double labeling study in the rat. The Journal of Comparative Neurology, vol. 373 (no. 4), pp. 498-510, September 30, 1996. To see the abstract, go to the PubMed.

72. Li J.-L., Kaneko T., Mizuno N., Effects of peripheral nerve ligation on expression of μ-opioid receptor in sensory ganglion neurons: and immunohistochemical study in dorsal root and nodose ganglion neurons of the rat. Neuroscience Letters, vol. 214 (no. 2-3), pp. 91-94, August 23,1996. To get this, click pdf-8.jpg. To see the abstract, go to the PubMed.

R-5. 水野昇, 李金蓮, 李和, 丁玉強, 金子武嗣, 野村嶬, 痛覚系におけるμオピオイド受容体, 細胞 28 (13), 470-474, 1996.

59. Li Y.-Q., Takada M., Kaneko T., Mizuno N., Premotor neurons for trigeminal motor nucleus neurons innervating the jaw-closing and jaw-opening muscles: Differential distribution in the lower brainstem of the rat. The Journal of Comparative Neurology, vol. 365 (no. 4), pp. 563-579, January 22, 1995. To see the abstract, go to the PubMed.


4-4) Autonomic nervous system

175. Ito T, Hioki H, Nakamura Ko, Tanaka Y, Nakade H, Kaneko T, Iino S, Nojyo Y, GABA-containing sympathetic preganglionic neurons in rat thoracic spinal cord send their axons to the superior cervical ganglion. The Journal of Comparative Neurology, vol. 502 (no. 1), pp. 113-125, May 1, 2007. To get this, click pdf-5-1.jpg. To see the abstract, go to the PubMed (17335042). PhD (Fukui Univ) paper of Dr. T Ito.

164. Nakamura Y, Nakamura Ka, Matsumura K, Kobayashi S, Kaneko T, Morrison SF, Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. European Journal of Neuroscience, vol. 22 (no. 12), pp. 3137-3146, December, 2005 (online; ?). To get this, click pdf-41.jpg. To see the abstract, go to the PubMed (16367780). Young Scientist Award in Second International Meeting on Pysiology and Pharmacology of Temperature Regulation (March 2006, Phoenix, Arizona). PhD paper of Dr. Y Nakamura.

R-17. Nakamura K., Matsumura K., Kobayashi S., Kaneko T., Sympathetic premotor neurons mediating thermoregulatory functions. Neuroscience Research, vol.51 (no. 1), pp. 1-8, January, 2005 (online; November 5). To get this, click pdf-11-1.jpg. To see the abstract, go to the PubMed.

151. Nakamura Ka, Matsushima K, Hubschle T, Nakamura Y, Hioki H, Fujiyama F, Boldogkoi Z, Konig M, Thiel H-J, Gerstberger R, Kobayashi S, Kaneko T, Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. The Journal of Neuroscience, vol. 24 (no. 23), pp. 5370-5380, June 9, 2004. To get this, click pdf-29.jpg. To see the abstract, go to the PubMed (15190110).

149. Nakamura Ka., Wu S.-X., Fujiyama F., Okamoto K., Hioki H., Kaneko T., Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons. NeuroReport, vol. 15 (no.3), pp. 431-436, March 1, 2004. To get this, click pdf-28-46.jpg. To see the abstract, go to the PubMed (15094498).

129. Nakamura K., Matsumura K., Kaneko T., Kobayashi S., Katoh H., Negishi M., The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. The Journal of Neuroscience, vol. 22 (no. 11), pp. 4600-4610, June 1, 2002. To get this, click pdf-28-26.jpg. To see the abstract, go to the PubMed.

58. Ding Y.-Q., Takada M., Kaneko T. Mizuno N., Colocalization of vasoactive intestinal polypeptide and nitric oxide in penis-innervating neurons in the major pelvic ganglion of the rat. Neuroscience Research vol. 22 (no. 1), pp. 129-131, March, 1995. To get this, click pdf-1-1.jpg. To see the abstract, go to the PubMed.

11. Konishi A., Itoh K., Sugimoto T., Yasui Y., Kaneko T., Takada M., Mizuno N., Leucine-enkephalin-like immunoreactive afferent fibers to pudendal motoneurons in the cat. Neuroscience Letters, vol. 61 (no. 1-2), pp. 109-113, October 24, 1985. To see the abstract, go to the PubMed.


4-6) Other CNS regions

200. Hioki H, Nakamura H, Ma Y-F, Konno M, Hayakawa T, Nakamura KC, Fujiyama F, Kaneko T.  Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei.  The Journal of Comparative Neurology, vol. 518 (no. 5), pp. 668-686, March 1, 2010 (online, October 13, 2009).  To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1-1-1-1-1-1-1.jpg.    To see the abstract, go to PubMed PMID 20034056.

181. Ito T. Hioki H, Nakamura Ko, Kaneko T, Iino S, Nojyo Y, Some gamma-motoneurons contain gamma-aminobutyric acid in the rat cervical spinal cord. Brain Research, vol. 1201, pp. 78-87, March 27, 2008 (online, February 2). To get this, click . To see the abstract, go to the PubMed (18294622).

136. Hioki H., Fujiyama F., Taki K., Tomioka R., Furuta T., Tamamaki N., Kaneko T., Differental distribution of vesicular glutamate transporters in the rat cerebellar cortex. Neuroscience, vol. 117 (no. 1), pp. 1-6, March 17, 2003. To get this, click pdf-28-33.jpg. To see the abstract, go to the PubMed.

114. Li Y.-Q., Li H., Kaneko T., Mizuno N., Morphological features and electrophysiological properties of serotonergic and non -serotonergic projection neurons in the dorsal raphe nucleus. An intracellular recording and labeling study in rat brain slices. Brain Research, vol. 900 (no. 1), pp. 110-118, May 4, 2001. To get this, click pdf-28-12.jpg. To see the abstract, go to the PubMed.

111. Li Y.-Q., Kaneko T., Mizuno N., Collateral projections of nucleus raphe dorsalis neurones to the caudate-putamen and region around the nucleus raphe magnus and nucleus reticularis gigantocellularis pars α in the rat. Neuroscience Letters, vol. 299 (no. 1-2), pp. 33-36, February 16, 2001. To get this, click pdf-28-9-1.jpg. To see the abstract, go to the PubMed.

5. Itoh K., Kaneko T., Kudo M., Mizuno N., The intercollicular region in the cat: a possible relay in the parallel somatosensory pathways from the dorsal column nuclei to the posterior complex of the thalamus. Brain Research, vol. 308 (no. 1), pp. 166-171, August 6, 1984. To see the abstract, go to the PubMed.


5) Localization of Transmitters and Receptors

5-1) Glutamatergic neurons

199. Bitanihirwe BKY, Lim MP, Kelley JF, Kaneko T, Woo TUW;  Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia.  BMC Psychiatry vol 9 (no 1), article 71, November 16, 2009.  To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1-1-1-1-1-1.jpg.  To see the abstract, go to PubMed PMID 19917115.

161. Nakamura Ko., Hioki H., Fujiyama F., Kaneko T., Postnatal changes of vesicular glutamate transpoter 1 (VGluT1) and VGluT2 and their colocalization in the mouse forebrain. The Journal of Comparative Neurology, vol. 492 (no. 3), pp. 263-288, October 10, 2005. To get this, click pdf-38.jpg. To see the abstract, go to the PubMed (16217795). PhD paper of Dr. Ko C Nakamura.

157. Fujiyama F., Kuramoto E., Okamoto K., Hioki H., Furuta T., Zhou L., Nomura S., Kaneko T., Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. European Journal of Neuroscience, vol. 20 (no. 12), pp. 3322-3330, December, 2004 (online; December 9). To get this, click pdf-35-2.jpg. To see the abstract, go to the PubMed (15610164).

153. Hioki H., Fujiyama F., Nakamura Ko., Wu S.-X., Matsuda W., Kaneko T., Chemically specific circuit composed by vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex. Cerebral Cortex, vol. 14 (no. 11), pp. 1266-1275, November, 2004 (online; May 13). To get this, click pdf-31-2.jpg. To see the abstract, go to the PubMed (15142960).  PhD paper of Dr. H. Hioki.

152. Wu S.-X., Koshimizu Y., Fenf Y.-P., Okamoto K., Fujiyama F., Hioki H., Li Y.-Q., Kaneko T., Mizuno N., Vesicular glutamate transporter immunoreactivty in the central and peripheral ending of muscle-spindle afferents. Brain Research, vol. 1011 (no. 2), pp. 247-251, June 18, 2004 (online; May 6). To get this, click pdf-30.jpg. To see the abstract, go to the PubMed (15157812).

149. Nakamura Ka., Wu S.-X., Fujiyama F., Okamoto K., Hioki H., Kaneko T., Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons. NeuroReport, vol. 15 (no.3), pp. 431-436, March 1, 2004. To get this, click pdf-28-46-1.jpg. To see the abstract, go to the PubMed (15094498).

142. Fujiyama F., Hioki H., Ryohei T., Taki K., Tamamaki N., Nomura S., Okamoto K., Kaneko T., Changes of immunocytochemical localization of vesicular glutamate transporters in the rat visual system after the retinofugal denervation. The Journal of Comparative Neurology, vol.4 65 (no.2), pp. 234-249, October 13, 2003. To get this, click pdf-28-39.jpg. To see the abstract, go to the PubMed.

139. Li J.-L., Xiong K.-H., Dong Y.-L., Fujiyama F., Kaneko T., Mizuno N., Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to the co-expression. The Journal of Comparative Neurology, vol. 463 (no.2), pp. 212-220, August 18, 2003. To get this, click pdf-28-36-1.jpg. To see the abstract, go to the PubMed.

136. Hioki H., Fujiyama F., Taki K., Tomioka R., Furuta T., Tamamaki N., Kaneko T., Differental distribution of vesicular glutamate transporters in the rat cerebellar cortex. Neuroscience, vol. 117 (no. 1), pp. 1-6, March 17, 2003. To get this, click pdf-28-33-1.jpg. To see the abstract, go to the PubMed.

135. Li J-L., Fujiyama F., Kaneko T., Mizuno N., Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat. The Journal of Comparative Neurology, vol. 457 (no. 3), pp. 236-249, March 10, 2003. To get this, click pdf-28-32-1.jpg. To see the abstract, go to the PubMed.

R-12. Kaneko T. and Fujiyama F., Complementary distribution of vesicular glutamate transporters in the central nervous system. Neuroscience Research, vol.42 (no. 4), pp. 243-250, April, 2002. To get this, click pdf-10-1.jpg. To see the abstract, go to the PubMed.

127. Kaneko T., Fujiyama F., Hioki H., Immunohistochemical localization of candidates for vesicular glutamate transporters in the rat brain. The Journal of Comparative Neurology, vol. 444 (no. 1), pp. 39-62, February 25, 2002. To get this, click pdf-28-24.jpg. To see the abstract, go to the PubMed.

115. Fujiyama F., Furuta T., Kaneko T., Immunocytochemical localization of candidates for vesicular glutamate transporters in the rat cerebral cortex. The Journal of Comparative Neurology, vol. 435 (no. 3), pp. 379-387, July 2, 2001. To get this, clickpdf-28-13-1.jpg . To see the abstract, go to the PubMed.

R-9. Kaneko T., Enzymes responsible for glutamate synthesis and degradation. In Handbook of Chemical Neuroanatomy, vol. 18: Glutamate, Chapter VII, pp. 203-230, 2000.

63. Kaneko T., Kang Y., Mizuno N., Glutaminase-positive and glutaminase-negative pyramidal cells in layer VI of the primary and somatosensory cortices: A combined analysis by intracellular staining and immunocytochemistry in the rat. The Journal of Neuroscience, vol. 15 (no. 12), pp. 8362-8377, December, 1995. To see the abstract, go to the PubMed.

54. Kaneko T., Mizuno N., Glutamate-synthesizing enzymes in GABAergic neurons of the neocortex: a double immunofluorescence study in the rat. Neuroscience, vol. 61 (no. 4), pp. 839-849, 1994. To see the abstract, go to the PubMed.

40. Kaneko T., Nakaya Y., Mizuno N., Paucity of glutaminase-immunoreactive nonpyramidal neurons in the rat cerebral cortex. The Journal of Comparative Neurology, vol. 322 (no. 2), pp. 181-190, August 8, 1992. To see the abstract, go to the PubMed.

38. Kaneko T., Mizuno N., Mosaic distribution of phosphate-activated glutaminase-like immunoreactivity in the rat neostriatum. Neuroscience, vol. 49 (no. 2), pp. 329-345, 1992. To see the abstract, go to the PubMed.

37. Kaneko T., Hanazawa A., Mizuno N., Enhancement of glutaminase-like immunoreactivity in rat brain by an irreversible inhibitor of the enzyme. Brain Resarch Bulletin, vol. 28 (no. 6), pp. 897-907, June, 1992. To see the abstract, go to the PubMed.

R-4. Kaneko T. and Mizuno N., Postnatal change of glutaminase-containing neurons in the olfactory bulb, thalamus, cerebral cortex and cerebellum of the rat. In: Handbook of Chemical Neuroanatomy, Vol. 10, Ontogeny of Transmitters and Peptides in the CNS (eds. Björklund A., Hökfelt T. and Tohyama M.), pp. 177-195, Elsevier, Amsterdam, 1992.

R-3. 金子武嗣, 中枢神経系内での興奮性アミノ酸の生合成代謝, 細胞 23 (5), 151-155, 1991.

30. Akiyama H., Kaneko T., Mizuno N. and McGeer P. L., Distribution of phosphate-activated glutaminase in the human cerebral cortex. The Journal of Comparative Neurology, vol. 297 (no. 2), pp. 239-252, July 8, 1990. To see the abstract, go to the PubMed.

29. Kaneko T., Akiyama H., Nagatsu I., Mizuno N., Immunohistochemical demonstration of glutaminase in catecholaminergic and serotoninergic neurons of rat brain. Brain Research, vol. 507 (no. 1), pp. 151-154, January 15, 1990. To see the abstract, go to the PubMed.

28. Kaneko T., Itoh K., Shigemoto R., Mizuno N., Glutaminase-like immunoreactivity in the lower brainstem and cerebellum of the adult rat. Neuroscience, vol. 32 (no. 1), pp. 79-98, January 15, 1989. To see the abstract, go to the PubMed.

26. Akiyama H., McGeer P. L., Itagaki S., McGeer E. G. and Kaneko T., Loss of glutaminase-positive cortical neurons in Alzheimer's disease. Neurochemical Research, vol. 14 (no. 4), pp. 353-358, April, 1989. To see the abstract, go to the PubMed.

21. Kaneko T., Urade Y., Mizuno N., Correlation between immunochemical characteristics and immunohistochemical applicability of nine lines of monoclonal antibodies against rat brain glutaminase. The Journal of Histochemistry and Cytochemistry, vol. 36 (no. 8), pp. 997-1004, August, 1988. To see the abstract, go to the PubMed.

20. Kaneko T., Shigemoto R., Mizuno N., Metabolism of glutamate and ammonia in astrocytes: An immunocytochemical study. Brain Research vol. 457 (no. 1), pp. 160-164, August 2, 1988. To see the abstract, go to the PubMed.

19. Kaneko T., Mizuno N., Immunohistochemical study of glutaminase-containing neurons in the cerebral cortex and thalamus of the rat. The Journal of Comparative Neurology, vol. 267 (no. 4), pp. 590-602, January 22, 1988. To see the abstract, go to the PubMed. PhD paper of Dr. Kaneko.

17. Kaneko T., Akiyama H., Mizuno N., Immunohistochemical demonstration of glutamate dehydrogenase in astrocytes. Neuroscience Letters, vol. 77 (no. 2), pp. 171-176, June 15, 1987. To see the abstract, go to the PubMed.

15. Kaneko T., Urade Y., Watanabe Y., Mizuno N., Production, characterization, and immunohistochemical application of monoclonal antibodies to glutaminase purified from rat brain. The Journal of Neuroscience, vol. 7 (no. 1), pp. 302-309, January, 1987. To see the abstract, go to the PubMed.


5-2) Metabotropic glutamate teceptors

74. Neki A., Ohishi H., Kaneko T., Shigemoto R., Nakanishi S., Mizuno N., Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience, vol. 75 (no. 3), pp. 815-826, December, 1996. To get this, click pdf-8-1.jpg. To see the abstract, go to the PubMed.

70. Shigemoto R., Kulik A., Roberts J. D. B., Ohishi H., Nusser Z., Kaneko T., Somogyi P., Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature, vol. 381 (no. 6582), pp. 523-525, June 6, 1996. To see the abstract, go to the PubMed.

65. Li J.-L., Ohishi H., Kaneko T., Shigemoto R., Neki A., Nakanishi S., and Mizuno N., Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Neuroscience Letters, vol. 204 (no. 1-2), pp. 9-12, February 2, 1996. To get this, click pdf-4.jpg. To see the abstract, go to the PubMed.

64. Neki A., Ohishi H., Kaneko T., Shigemoto R., Nakanishi S., and Mizuno N., Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: an immunohistochemical study with a monoclonal antibody. Neuroscience Letters, vol. 202 (no. 3), pp. 197-200, January 5, 1996. To get this, click pdf-3-1.jpg. To see the abstract, go to the PubMed.

53. Ohishi H., Ogawa-Meguro R., Shigemoto R., Kaneko T., Nakanishi S., Mizuno N., Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron, vol. 13 (no. 1), pp. 55-66, July, 1994. To see the abstract, go to the PubMed.


5-3) Opioid receptor

R-5. 水野昇, 李金蓮, 李和, 丁玉強, 金子武嗣, 野村嶬, 痛覚系におけるμオピオイド受容体, 細胞 28 (13), 470-474, 1996.

1996.

69. Nomura S., Ding Y.-Q., Kaneko T., Li J.-L., Mizuno N., Localization of μ-opioid receptor-like immunoreactivity in the central components of the vagus nerve: a light and electron microscope study in the rat. Neuroscience, vol. 73 (no. 1), pp. 277-286, July, 1996. To get this, click pdf-7.jpg. To see the abstract, go to the PubMed.

66. Ding Y.-Q., Kaneko T., Nomura S., Mizuno N., Immunohistochemical localization of μ-opioid receptors in the central nervous system of the rat. The Journal of Comparative Neurology, vol. 367 (no. 3), pp. 375-402, April 8, 1996. To see the abstract, go to the PubMed.

62. Ding Y.-Q., Nomura S., Kaneko T., Mizuno N., Presynaptic localization of μ-opioid receptor-like immunoreactivity in retinal axon terminals within the terminal nuclei of the accessory optic tract: a light and electron microscopic study in the rat. Neuroscience Letters, vol. 199 (no. 2), pp. 139-142, October 20, 1995. To get this, click pdf-3.jpg. To see the abstract, go to the PubMed.

61. Ding Y.-Q., Nomura S., Kaneko T., Mizuno N., Co-colocalization of μ-opioid receptor-like and substance P-like immunoreactivities in axon terminals within the superficial layers of the medullary and spinal dorsal horns of the rat. Neuroscience Letters, vol. 198 (no. 1), pp. 45-48, September 22, 1995. To get this, click pdf-2.jpg. To see the abstract, go to the PubMed.

57. Kaneko T., Minami M., Satoh M., Mizuno N., Immunocytochemical localization of μ-opioid receptor in the rat caudate-putamen. Neuroscience Letters, vol. 184 (no. 3), pp. 149-152, January 30, 1995. To get this, click pdf-1.jpg. To see the abstract, go to the PubMed.


5-4) Substance P and its receptor

71. Tokuno H., Takada M., Kaneko T., Shigemoto R., Mizuno N., Patchy distribution of substance P receptor immunoreactivity in the developing rat striatum. Developmental Brain Research, vol. 95 (no. 1), pp. 107-117, August 20, 1996.  To see the abstract, go to the PubMed.

55. Nakaya Y., Kaneko T., Shigemoto R., Nakanishi S., Mizuno N., Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. The Journal of Comparative Neurology, vol. 347 (no. 2), pp. 249-274, September 8, 1994. To see the abstract, go to the PubMed.

49. Kaneko T., Shigemoto R., Nakanishi S., Mizuno N., Morphological and chemical characteristics of substance P receptor-immunoreactive neurons in the rat neocortex. Neuroscience, vol. 60 (no. 1), pp. 199-211, January, 1994. To see the abstract, go to the PubMed.

48. Kaneko T., Shigemoto R., Nakanishi S., Mizuno N., Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic aspiny neurons. Brain Research vol. 631 (no. 2), pp. 297-303, December 24, 1993. To see the abstract, go to the PubMed.

43. Shigemoto R., Nakaya Y., Nomura S., Ogawa-Meguro R., Ohishi H., Kaneko T., Nakanishi S. and Mizuno N., Immunocytochemical localization of rat substance P receptor in the striatum. Neuroscience Letters, vol. 153 (no. 2), pp. 157-160, April 30, 1993. To see the abstract, go to the PubMed.


5-5) Prostaglandins and their receptors

164. Nakamura Y, Nakamura Ka, Matsumura K, Kobayashi S, Kaneko T, Morrison SF, Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. European Journal of Neuroscience, vol. 22 (no. 12), pp. 3137-3146, December, 2005 (online; ?). To get this, click pdf-41-1.jpg. To see the abstract, go to the PubMed (16367780). Young Scientist Award in Second International Meeting on Pysiology and Pharmacology of Temperature Regulation (March 2006, Phoenix, Arizona). PhD paper of Dr. Y Nakamura.

119. Mizoguchi A., Eguchi N., Kimura K., Kiyohara Y., Qu W.-M., Huang Z.-L., Mochizuki T., Lazarus M., Kobayashi T., Kaneko T., Narumiya S., Urade Y., Hayashi O., Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proceedings of National Academy of Sciences U.S.A., vol. 98 (no. 20), pp. 11674-11679, September 25, 2001. To get this, click pdf-28-17.jpg. To see the abstract, go to the PubMed.

113. Nakamura K., Li Y.-Q., Kaneko T., Katoh H., and Negishi M., Prostaglandin EP3 Receptor protein in serotonin and catecholamine cell groups: A double immunofluorescence study in the rat brain, Neuroscience, vol. 103 (no. 3), pp. 763-775, March 21, 2001. To get this, click pdf-28-11.jpg. To see the abstract, go to the PubMed.

108. Beuckmann C.T., Lazarus M., Gerashchenko D., Mizoguchi A., Nomura S., Mohri I., Uesugi A., Kaneko T., Mizuno N., Hayaishi O., Urade Y., Cellular localization of lipocalin-type prostaglandin D synthase (β-trace) in the central nervous system of the adult rat. The Journal of Comparative Neurology, vol. 428 (no. 1), pp. 62-78, December 25, 2000. To get this, clickpdf-28-6.jpg . To see the abstract, go to the PubMed.

98. Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., Negishi M., Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. The Journal of Comparative Neurology, vol. 421 (no. 4), pp. 543-569, June 12, 2000. To get this, click pdf-25.jpg. To see the abstract, go to the PubMed.

89. Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., Ichikawa A., Negishi M., Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neuroscience Letters, vol. 260 (no.2), pp. 117-120, January 29, 1999.  To get this, click pdf-17.jpg. To see the abstract, go to the PubMed.

46. Urade Y., Kitahama K., Ohishi H., Kaneko T., Mizuno N. and Hayaishi O., Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and ologodendrocytes of the adult rat brain. Proceedings of National Academy of Sciences U.S.A., vol. 90 (no. 19), pp. 9070-9074, October 1, 1993. To get this, click pdf.jpg. To see the abstract, go to the PubMed.

41. Eguchi N., Kaneko T., Urade Y., Hayashi H., Hayaishi O., Permeability of brain structure and other peripheral tissues to prostaglandin D2, E2 and F2a in rats. The Journal of Pharmacology and Experimental Therapeutics, vol. 262 (no. 3), pp. 1110-1120, September, 1992. To see the abstract, go to the PubMed.

39. Fujimoto N., Kaneko T., Eguchi N., Urade Y., Mizuno N. and Hayaishi O., Biochemical and immunohistochemical demonstration of a tightly bound form of prostaglandin E2 in the rat brain. Neuroscience, vol. 49 (no. 3), pp. 591-606, August, 1992. To see the abstract, go to the PubMed.

18. Urade Y., Fujimoto N., Kaneko T., Konishi A., Mizuno N., Hayaishi O., Postnatal changes in the localization of prostaglandin D synthetase from neurons to oligodendrocytes in the rat brain. The Journal of Biological Chemistry, vol. 262 (no. 31), pp. 15132-15136, November 5, 1987. To see the abstract, go to the PubMed.


6) Development and adult neurogenesis of the CNS

196.  Nakamura KC, Fujiyama F, Furua T, Hioki H, Kaneko T.  Afferent islands are larger than µ-opioid receptor patch in striatum of rat pups.  NeuroReport,vol 20 (no 6), pp 584-588, April 22, 2009 (online, March 12). To get this, click pdf-9-1-1-1-1-1-2-1-1-1-1-1-1.jpg.  To see the abstract, go to PubMed (19287319).

192.  Ide Y, Fujiyama F, Okamoto-Furuta K, Tamamaki N, Kaneko T, Hisatsune T.  Rapid integration of young newborn dentate gyrus granule cells into the adult hippocampal circuitry.  European Journal of Neuroscience, vol. 28 (no. 12): 2381-2392, December, 2008 (online, December 9).   To get this, click pdf-9-1-1-1-1-1-2-1-1-2.jpg.  To see the abstract, go to PubMed (19087169).  PhD paper (Univ of Tokyo) of Dr. Y. Ide.

178. Nakamura Ko, Watakabe A, Hioki H, Fujiyama F, Tanaka Y, Yamamori T, Kaneko T, Transiently increased colocalization of vesicular glutamate transporters 1 and 2 at single axon terminals during postnatal development of mouse neocortex: a quantitative analysis with correlation coefficient. European Journal of Neuroscience, vol. 26 (no. 8), pp. 3054-3067, December, 2007. (online, November 16). To get this, click pdf-8-1-1.jpg. To see the abstract, go to the PubMed (18028110).  Erratum (vol 28 (no. 5): 1032-46, Sep, 2008; online, 26 August).  Supplemental Table.  Supplemantal Figure.

165. Nakamura Ka, Yamashita Y, Tamamaki N, Katoh H, Kaneko T, Negishi M, In vivo function of Rnd2 in the development of neocortical pyramidal neurons. Neuroscience Research, vol. 54 (no. 2), pp. 149-153, February, 2006 (online; November 21, 2005). To get this, click pdf-42.jpg. To see the abstract, go to the PubMed (16303198).

163. Wu S-X, Goebbels S, Nakamura Ko, Kometani K, Minato N, Kaneko T, Nave K-A, Tamamaki N, Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone. Proceedings of National Academy of Sciences USA, vol. 102 (no. 47), pp.17172-17177, November 22, 2005 (online; November 11). To get this, click pdf-40.jpg. To see the abstract, go to the PubMed (16284248).

161. Nakamura Ko., Hioki H., Fujiyama F., Kaneko T., Postnatal changes of vesicular glutamate transpoter 1 (VGluT1) and VGluT2 and their colocalization in the mouse forebrain. The Journal of Comparative Neurology, vol. 492 (no. 3), pp. 263-288, October 10, 2005. To get this, click pdf-38-1.jpg. To see the abstract, go to the PubMed (16217795). PhD paper of Dr. Ko C Nakamura.

118. Tamamaki N., Nakamura K., Okamoto K., Kaneko T., Radial glia is a progenitor of neocortical neurons in the developing cerebral cortex. Neuroscience Research, vol. 41 (no. 1), pp. 51-60, September, 2001. To get this, click pdf-28-16.jpg. To see the abstract, go to the PubMed. Honored with Neuroscience Research Excellent Paper Award.

R-4. Kaneko T. and Mizuno N., Postnatal change of glutaminase-containing neurons in the olfactory bulb, thalamus, cerebral cortex and cerebellum of the rat. In: Handbook of Chemical Neuroanatomy, Vol. 10, Ontogeny of Transmitters and Peptides in the CNS (eds. Björklund A., Hökfelt T. and Tohyama M.), pp. 177-195, Elsevier, Amsterdam, 1992.

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